Chi D. Luu, PhD

New research reports the relative ellipsoid zone reflectivity (rEZR) is significantly reduced in subjects with intermediate age-related macular degeneration (iAMD) over a 3-year period.

The findings suggest both the presence and increasing extent of coexistent reticular pseudodrusen (RPD) at baseline were associated with a faster rate of decline.

“These results warrant further studies to understand the value of rEZR as the biomarker associated with AMD progression, ” wrote study author Chi D. Luu, PhD, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital.

Luu and colleagues indicate that rEZR has been reported to be reduced in patients with iAMD, but the longitudinal changes seen in rEZR has remained unknown. As a result, they set out to investigate the natural history of rEZR in iAMD and its association with risk factors with regard to disease development, including the particular presence or extent associated with drusen volume, RPD, plus pigmentary abnormalities (PAs).

The longitudinal observational study included participants along with bilateral large drusen. Investigators collected spectral-domain optical coherence tomography (OCT) images of both eyes from each individual every 6 months for 3 years. Then, with an automated rEZR determination approach, the average rEZR of the central 20° macula was calculated for each SD-OCT volume scan.

Meanwhile, linear mixed models were used to determine the price of change in rEZR with age using cross-sectional data at baseline and over time using longitudinal data, as well as the interactions between the rate of rEZR changes with AMD risk factors in baseline. Main outcomes regarding the study included the relative ellipsoid zone reflectivity and its rate associated with change along with age plus with time.

The particular study incorporated a total of 280 eyes from 140 topics with bilateral large drusen. The cross-sectional findings showed that rEZR reduces with increasing age group (‒8. 4 arbitrary units [AUs] per decade; 95% confidence interval [CI], –11. 5 to ‒5. 2; P < 0. 001).

Moreover, the longitudinal data show that rEZR declined from a rate of ‒2. 1 AU per year on average (95% CI, –2. 6 to –1. 6 AU each year; P <. 001). A larger RPD area ( P =. 042) with baseline was linked in order to a faster rate of rEZR decrease as time passes.

On the other hand, the presence of PAs and the drusen quantity at baseline showed no significant organization with rEZR decline over time ( P sama dengan. 068 and P =. 529, respectively).

The abstract, “Natural History of the Relative Ellipsoid Area Reflectivity within Age-Related Macular Degeneration, ” was published in Ophthalmology .

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