• Collaboration leverages HotSpot’s Smart Allostery™  drug discovery platform for the development of the first and only small molecule IRF5 (interferon regulatory factor 5) inhibitor for that potential treatment of autoimmune diseases
  • HotSpot to receive an upfront cash payment of $40 million with potential for further milestones and royalties

NORTH CHICAGO, Ill. and BOSTON , Dec. 6, 2022 /PRNewswire/ — AbbVie (NYSE: ABBV) and Killer spot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of small chemical allosteric therapies for the remedying of cancer and autoimmune diseases, today announced an exclusive worldwide collaboration plus option to license agreement for HotSpot’s discovery-stage IRF5 program for the treatment of autoimmune diseases.

“This collaboration with HotSpot has the particular potential in order to deliver an entirely new target class associated with modulators to be able to patients along with serious autoimmune diseases, such as systemic lupus erythematosus, and will help for you to further strengthen our robust immunology pipeline, ” said Jonathon Sedgwick , Ph. D., vice president in addition to global head of finding research, AbbVie. “HotSpot’s medication discovery system has been able to identify molecules that bind to help IRF5 in a predictable, reproducible manner potentially enabling effective drugging regarding what continues to be considered an undruggable target. ”

IRF5 is a transcription element that acts as the key regulator of certain types of immune responses, and even its dysregulation is strongly implicated in several poorly treated autoimmune disorders. Efforts to modulate IRF5 using conventional small particle approaches have been unsuccessful because IRF5 lacks a traditional active site. Leveraging its proprietary Smart Allostery™ program, HotSpot discovered what it believes to be the first and only disclosed small molecule IRF5 inhibitor that targets a previously unknown allosteric pocket on the protein that is critical for the endogenous regulation – a new “natural hotspot”.

“Today’s contract with AbbVie underscores our significant progress in rapidly building a substantial pipeline involving novel allosteric small chemical therapeutic candidates for your treatment of autoimmune diseases together with cancer, ” said Jonathan Montagu , Co-Founder and additionally Chief Executive Officer connected with HotSpot Therapeutics. “We look forward to collaborating together with AbbVie, an industry leader in developing not to mention commercializing important immunology therapeutics. ”

Under the terms with the arrangement, HotSpot will receive a good upfront cash payment for $40 million and may be eligible in order to receive up to $295 million in option fees and also research as well as development milestones, with potential for further commercial milestones as well as tiered royalties on global net sales. Should AbbVie exercise their option to be able to license, AbbVie will conduct all future clinical advancement, manufacturing and commercialization activities for the IRF5 inhibitor program. In addition , Killer spot would have an one-time choice to share in worldwide R& D costs in exchange for increased royalty payments. Aquilo Partners, L. P. acted as financial advisor to HotSpot on this transaction.

About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges about tomorrow. We strive for you to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology and gastroenterology, in addition to products and services across it is Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on Twitter , Facebook , Instagram , YouTube plus LinkedIn .

About HotSpot Therapeutics, Inc.
Killer spot Therapeutics, Incorporation. is groundbreaking a new class in allosteric drugs that focus on certain naturally occurring pockets on proteins called “natural hotspots. inch These pockets are decisive in controlling a protein’s cellular function and have significant possibility of new drug breakthrough by enabling the systematic design of potent and selective small molecules with novel pharmacology. The company’s proprietary Smart Allostery™ platform combines computational approaches and AI-driven data mining of large and diverse data sets to uncover hotspots with tailored pharmacology toolkits and bespoke chemistry to help drive typically the rapid breakthrough discovery of novel hotspot-targeted small molecules. Leveraging this approach, HotSpot is building a broad pipeline from novel allosteric therapies with regard to the treatment of cancer in addition to autoimmune illnesses. To learn more, visit  www.hotspotthera.com .

Forward-Looking Statements
Some statements in this particular news release are, or may be considered, forward-looking statements regarding purposes of this Private Securities Litigation Reform Act of 1995. The particular words “believe, ” “expect, ” “anticipate, ” “project” and similar expressions, among others, generally determine forward-looking claims. AbbVie cautions that these forward-looking statements are subject to risks and uncertainties that might cause actual results to differ materially from those indicated in the forward-looking statements. Such risks and even uncertainties include, but are not limited to, failure to realize often the expected benefits from AbbVie’s acquisition associated with Allergan plc (“Allergan”), failing to promptly and effectively integrate Allergan’s businesses, competition from other items, challenges to intellectual property, difficulties inherent within the research and growth process, adverse litigation or even government action, changes to laws and regulations applicable in order to our industry and your impact regarding public health outbreaks, epidemics or perhaps pandemics, such as COVID-19. Additional info about the economic, competitive, governmental, technological together with other factors that may possibly affect AbbVie’s operations will be set forth in Item 1A, “Risk Factors, inches of AbbVie’s 2021 Annual Report upon Form 10-K, which has been filed with the exact Securities and additionally Exchange Commission, as updated by it has the subsequent Quarterly Reports on Form 10-Q. AbbVie undertakes no obligation to release publicly any revisions to forward-looking statements as a result of subsequent events or maybe developments, except as required by law.


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